Journal article

Outcomes of Resistance-guided Sequential Treatment of Mycoplasma genitalium Infections: A Prospective Evaluation

Tim RH Read, Christopher K Fairley, Gerald L Murray, Jorgen S Jensen, Jennifer Danielewski, Karen Worthington, Michelle Doyle, Elisa Mokany, Litty Tan, Eric PF Chow, Suzanne M Garland, Catriona S Bradshaw

CLINICAL INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2019

Abstract

Background: Rising macrolide and quinolone resistance in Mycoplasma genitalium necessitate new treatment approaches. We evaluated outcomes of sequential antimicrobial therapy for M. genitalium guided by a macrolide-resistance assay. Methods: In mid-2016, Melbourne Sexual Health Centre switched from azithromycin to doxycycline (100 mg twice daily for 7 days) for nongonococcal urethritis, cervicitis, and proctitis. Cases were tested for M. genitalium and macrolide-resistance mutations (MRMs) by polymerase chain reaction. Directly after doxycycline, MRM-negative infections received 2.5 g azithromycin (1 g, then 500 mg daily for 3 days), and MRM-positive infections received sitafloxacin (100 mg ..

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