Journal article

Efficacy of intra-articular injections of platelet-rich plasma as a symptom- and disease-modifying treatment for knee osteoarthritis - the RESTORE trial protocol

Kade L Paterson, David J Hunter, Ben R Metcalf, Jillian Eyles, Vicky Duong, Jessica Kazsa, Yuanyuan Wang, Rachelle Buchbinder, Flavia Cicuttini, Andrew Forbes, Anthony Harris, Shirley P Yu, Bing Hui Wang, David Connell, James Linklater, Kim L Bennell

BMC MUSCULOSKELETAL DISORDERS | BMC | Published : 2018

Abstract

BACKGROUND: Knee osteoarthritis (OA) causes substantial pain, physical dysfunction and impaired quality of life. There is no cure for knee OA, and for some people, the disease may involve progressive symptomatic and structural deterioration over time. Platelet-rich plasma (PRP) is a therapeutic agent that aims to address underlying biological processes responsible for OA pathogenesis. As such, it has the potential to improve both symptoms and joint structure. The aim of this clinical trial is to determine whether a series of injections of PRP into the knee joint will lead to a significantly greater reduction in knee pain, and less loss of medial tibial cartilage volume over 12 months when co..

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Grants

Awarded by National Health and Medical Research Council


Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NHMRC Practitioner Fellowship


Awarded by NHMRC


Awarded by NHMRC Senior Principal Research Fellowship


Funding Acknowledgements

This study is funded by the National Health and Medical Research Council (ID: 1106274). KLB is a National Health and Medical Research Council (NHMRC) Principal Research Fellow (1058440). DJH is supported by an NHMRC Practitioner Fellowship (1079777). BHW is supported by a NHMRC program grant (1092642). RB is funded by an NHMRC Senior Principal Research Fellowship (1082138).