Journal article
Progression-free survival at 24 months (PFS24) and subsequent outcome for patients with diffuse large B-cell lymphoma (DLBCL) enrolled on randomized clinical trials
MJ Maurer, TM Habermann, Q Shi, N Schmitz, D Cunningham, M Pfreundschuh, JF Seymour, U Jaeger, C Haioun, H Tilly, H Ghesquieres, F Merli, M Ziepert, R Herbrecht, J Flament, T Fu, CR Flowers, B Coiffier
Annals of Oncology | Published : 2018
Abstract
Background: Patients with diffuse large B-cell lymphoma treated with first-line anthracycline-based immunochemotherapy and remaining in remission at 2 years have excellent outcomes. This study assessed overall survival (OS) stratified by progression-free survival (PFS) at 24 months (PFS24) using individual patient data from patients with DLBCL enrolled in multi-center, international randomized clinical trials as part of the Surrogate Endpoint for Aggressive Lymphoma (SEAL) Collaboration. Patients and methods: PFS24 was defined as being alive and PFS24 after study entry. OS from PFS24 was defined as time from identified PFS24 status until death due to any cause. OS was compared with each pati..
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Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported by grants from Celgene Corporation. Data were transmitted directly from original study cooperative groups to the Mayo Clinic. Celgene Corporation supported organization and meetings of the SEAL group. The National Institutes of Health University of Iowa/Mayo Clinic Lymphoma SPORE (CA97274) grant provided support for MJM and TMH.