Journal article

Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women

Minouk J Schoemaker, Hazel B Nichols, Lauren B Wright, Mark N Brook, Michael E Jones, Katie M O'Brien, Hans-Olov Adami, Laura Baglietto, Leslie Bernstein, Kimberly A Bertrand, Marie-Christine Boutron-Ruault, Tonje Braaten, Yu Chen, Avonne E Connor, Miren Dorronsoro, Laure Dossus, A Heather Eliassen, Graham G Giles, Susan E Hankinson, Rudolf Kaaks Show all



Importance: The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) and risk of breast cancer is unique in cancer epidemiology in that a crossover effect exists, with risk reduction before and risk increase after menopause. The inverse association with premenopausal breast cancer risk is poorly characterized but might be important in the understanding of breast cancer causation. Objective: To investigate the association of BMI with premenopausal breast cancer risk, in particular by age at BMI, attained age, risk factors for breast cancer, and tumor characteristics. Design, Setting, and Participants: This multicenter anal..

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Awarded by Avon Foundation

Awarded by US National Center for Advancing Translational Sciences

Awarded by Karolinska Institutet

Awarded by US National Institutes of Health (NIH)

Awarded by National Institute of Environmental Health Sciences, NIH

Awarded by National Cancer Institute

Awarded by Breast Cancer Research Foundation

Awarded by European Research Council (Norway)

Awarded by Health Research Fund

Awarded by Cancer Research UK

Awarded by VicHealth

Awarded by Medical Research Council (United Kingdom)

Awarded by Instituto de Salud Carlos III Redes Tematicas de Investigacion Cooperativa en Salud, Spain



Funding Acknowledgements

This study was supported in part by Breast Cancer Now and the United Kingdom National Health Service funding to the Royal Marsden/Institute of Cancer Research National Institute for Health Research Biomedical Research Centre; The Institute of Cancer Research; grant 02-2014-080 from the Avon Foundation; grant KL2-TR001109 from the US National Center for Advancing Translational Sciences; Distinguished Professor Award 2368/10-221 from the Karolinska Institutet; grants R01CA144032 and R01UM182876 from the US National Institutes of Health (NIH); grants Z01 ES044005 and P30 ES000260 from the National Institute of Environmental Health Sciences, NIH; grants UM1 CA176726, UM1 CA186107, UM1 CA182876, UM1 CA182934, UM1 CA164974, R01 CA058420, R01 CA092447, CA077398, and CA144034 from the National Cancer Institute; the National Program of Cancer Registries of the Centers for Disease Control and Prevention; the US Department of Energy; The Dahod Breast Cancer Research Program at Boston University School of Medicine; the Maryland Cigarette Restitution Fund; grants 209057 and 396414 from VicHealth, Cancer Council Victoria, and the Australia National Health and Medical Research Council; grant BCRF-17-138 from the Breast Cancer Research Foundation; the Swedish Research Council and Swedish Cancer Foundation; the Japanese Ministry of Health, Labor and Welfare; and the Hellenic Health Foundation. The coordination of the European Prospective Investigation in Cancer is supported by the European Commission Health and Consumer Protection Directorate General and the International Agency for Research on Cancer. The national cohorts are supported by the Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l'Education Nationale, and Institut National de la Sante et de la Recherche Medicale (France); German Cancer Aid, German Cancer Research Center, Federal Ministry of Education and Research, Deutsche Krebshilfe, Deutsches Krebsforschungszentrum, and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-Italy and the National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports, the Netherlands Cancer Registry, LK Research Funds, Dutch Prevention Funds, Dutch Zorg Onderzoek Nederland, World Cancer Research Fund, and Statistics Netherlands (the Netherlands); European Research Council grant 2009-AdG 232997, Nordforsk, and Nordic Centre of Excellence Program on Food, Nutrition and Health (Norway); Health Research Fund PI13/00061 to Granada, PI13/01162 to EPIC-Murcia, Regional Governments of Andalucia, Asturias, Basque Country, Murcia, and Navarra, Instituto de Salud Carlos III Redes Tematicas de Investigacion Cooperativa en Salud, Spain (RD06/0020); the Swedish Cancer Society, Swedish Research Council, and County Councils of Skane and Vasterbotten (Sweden); and grant 14136 to European Prospective Study into Cancer and Nutrition (EPIC)-Norfolk and grants C570/A16491 and C8221/A19170 to EPIC-Oxford from Cancer Research UK, and grant 1000143 to EPIC-Norfolk and MR/M012190/1 to EPIC-Oxford from the Medical Research Council (United Kingdom).