Transcriptional signature primes human oral mucosa for rapid wound healing.
Ramiro Iglesias-Bartolome, Akihiko Uchiyama, Alfredo A Molinolo, Loreto Abusleme, Stephen R Brooks, Juan Luis Callejas-Valera, Dean Edwards, Colleen Doci, Marie-Liesse Asselin-Labat, Mark W Onaitis, Niki M Moutsopoulos, JS Gutkind, Maria I Morasso
Sci Transl Med | Published : 2018
Oral mucosal wound healing has long been regarded as an ideal system of wound resolution. However, the intrinsic characteristics that mediate optimal healing at mucosal surfaces are poorly understood, particularly in humans. We present a unique comparative analysis between human oral and cutaneous wound healing using paired and sequential biopsies during the repair process. Using molecular profiling, we determined that wound-activated transcriptional networks are present at basal state in the oral mucosa, priming the epithelium for wound repair. We show that oral mucosal wound-related networks control epithelial cell differentiation and regulate inflammatory responses, highlighting fundament..View full abstract