A review of commercially available thrombin generation assays

Abstract

Essentials Overview of the three commercial thrombin generation methods. Description of the sample preparation, data management, and analysis. Description of the similarities and differences in regards to substrates results. Discussion of advantages and disadvantages of the three approaches. Currently there are three commercially available thrombin generation methods. These methods help detect the levels of thrombin generated in patient samples by the use of chromogenic or fluorogenic substrates in plasma or whole blood. Determining the rate of thrombin generation can help indicate if patients are at risk of clotting or bleeding. This review discusses two fluorogenic and one chromogenic meth..