Journal article

An analytical approach for quantifying the influence of nanoparticle polydispersity on cellular delivered dose

Stuart T Johnston, Matthew Faria, Edmund J Crampin

JOURNAL OF THE ROYAL SOCIETY INTERFACE | ROYAL SOC | Published : 2018

Abstract

Nanoparticles provide a promising approach for the targeted delivery of therapeutic, diagnostic and imaging agents in the body. However, it is not yet fully understood how the physico-chemical properties of the nanoparticles influence cellular association and uptake. Cellular association experiments are routinely performed in an effort to determine how nanoparticle properties impact the rate of nanoparticle-cell association. To compare experiments in a meaningful manner, the association data must be normalized by the amount of nanoparticles that arrive at the cells, a measure referred to as the delivered dose. The delivered dose is calculated from a model of nanoparticle transport through fl..

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