Journal article

Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1

Axel Weber, Sigrid C Schwarz, Jorg Tost, Dietrich Truembach, Pia Winter, Florence Busato, Pawel Tacik, Anita C Windhorst, Maud Fagny, Thomas Arzberger, Catriona McLean, John C van Swieten, Johannes Schwarz, Daniela Vogt Weisenhorn, Wolfgang Wurst, Till Adhikary, Dennis W Dickson, Gunter U Hoelinger, Ulrich Mueller

Nature Communications | NATURE PUBLISHING GROUP | Published : 2018


Awarded by CurePSP

Awarded by French National Research Agency (ANR)

Awarded by BMBF

Awarded by Deutsche Forschungsgemeinschaft (DFG)

Funding Acknowledgements

We gratefully acknowledge technical support of Claudia Rohrsheim, Michaela Weis, and Stefanie Teschler (RT-qPCR, pyrosequencing), Monica Castanedes-Casey (immunohistochemistry), and Drs. Melissa Murray and Amanda Serie (Aperio technology). We thank Drs. Eilis Hannon and Jonathan Mill (University of Exeter Medical School) for the mQTL data of the adult prefrontal cortex. We also thank Drs. Per Hoffmann and Stefan Herms for advice on data analysis. Dr. Hong Xu is acknowledged for his help with DLX1 siRNA and tau overexpression experiments. We are indebted to Dr. Ellen Gelpi and Dr. Laura Molina at the Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Barcelona, for data and sample procurement. We thank Dr. Hagen Scherb (Institute of Computational Biology, Helmholtz Center Munich, Germany) for the support regarding statistical questions. This work was supported by a grant (#518-14) from CurePSP (to G.U.H., and U.M.), a German Federal Ministry of Education and Research (BMBF)-and French National Research Agency (ANR)-funded project on "Epigenomics of Parkinson's disease" (O1KU1403A/ ANR-13-EPIG-0003-05 EpiPD to G.U.H., J.T. and U.M.), the BMBF-funded project "HitTau" (01EK1605A to G.U.H.), the Deutsche Forschungsgemeinschaft (DFG, HO2402/6-2 & Munich Cluster for Systems Neurology SyNergy) (to G.U.H.), the NOMIS foundation (FTLD project to G.U.H.), the German Science Foundation Collaborative Research Center (CRC) 870 and the Helmholtz Portfolio Theme "Supercomputing and Modeling for the Human Brain" (SMHB) (to W.W., D.T. and D.V.W.), and the Bayerisches Staatsministerium fur Bildung und Kultus, Wissenschaft und Kunst within Bavarian Research Network "Human Induced Pluripotent Stem Cells" (ForIPS) (to G.U.H., S.C.S., W.W. and D.V.W.).