Journal article
Follicular B Cells Promote Atherosclerosis via T Cell-Mediated Differentiation Into Plasma Cells and Secreting Pathogenic Immunoglobulin G
C Tay, YH Liu, P Kanellakis, A Kallies, Y Li, A Cao, H Hosseini, P Tipping, BH Toh, A Bobik, T Kyaw
Arteriosclerosis Thrombosis and Vascular Biology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018
Abstract
OBJECTIVE: B cells promote or protect development of atherosclerosis. In this study, we examined the role of MHCII (major histocompatibility II), CD40 (cluster of differentiation 40), and Blimp-1 (B-lymphocyte-induced maturation protein) expression by follicular B (FO B) cells in development of atherosclerosis together with the effects of IgG purified from atherosclerotic mice. APPROACH AND RESULTS: Using mixed chimeric Ldlr-/- mice whose B cells are deficient in MHCII or CD40, we demonstrate that these molecules are critical for the proatherogenic actions of FO B cells. During development of atherosclerosis, these deficiencies affected T-B cell interactions, germinal center B cells, plasma ..
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Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
This work was supported by grants and fellowships from the National Health and Medical Research Council of Australia (Project Grant 1049416 to A. Kallies), the Sylvia and Charles Viertel Foundation (A. Kallies), the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support scheme.