Journal article

Evolutionary origins of the emergent ST796 clone of vancomycin resistant Enterococcus faecium

Andrew Buultjens, Margaret Lam, Susan Ballard, Ian Monk, Andrew Mahony, Elizabeth Grabsch, Lindsay Grayson, Stanley Pang, Geoffrey Coombs, Owen Robinson, Torsten Seemann, Paul Johnson, Benjamin Howden, Timothy Stinear

Published : 2016

Abstract

From early 2012, a novel clone of vancomycin resistant Enterococcus faecium (assigned the multi locus sequence type ST796) was simultaneously isolated from geographically separate hospitals in south eastern Australia and New Zealand. Here we describe the complete genome sequence of Ef_aus0233, a representative ST796 E. faecium isolate. We used PacBio single molecule real-time sequencing to establish a high quality, fully assembled genome comprising a circular chromosome of 2,888,087 bp and five plasmids. Comparison of Ef_aus0233 to other E. faecium genomes shows Ef_aus0233 is a member of the epidemic hospital-adapted lineage and has evolved from an ST555-like ancestral progenitor by the accu..

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