EFFICACY AND SAFETY OF GLECAPREVIR/PIBRENTASVIR IN PATIENTS WITH HCV GENOTYPE 5 OR 6 INFECTION: THE ENDURANCE-5, 6 STUDY

Abstract

The pangenotypic direct-acting antivirals (DAAs) glecaprevir (developed by AbbVie and Enanta)/pibrentasvir (G/P) are approved to treat chronic HCV genotype (GT)1–6 infection. In Phase 2 and 3 studies, G/P achieved high SVR12 rates with no virologic failures in 80 patients with GT5 or 6 infection. To increase the body of data for these genotypes, ENDURANCE-5,6 evaluates patients from countries where GT5 and GT6 are endemic, such as South Africa (GT5), Myanmar and Vietnam (GT6). This study evaluates the efficacy and safety of G/P in patients with chronic HCV GT5 or GT6 infection. ENDURANCE-5,6 is an ongoing phase 3b, non-randomised, open-label, multicenter study conducted in adults with chroni..