IL-9 Expression by Invariant NKT Cells Is Not Imprinted during Thymic Development.
Marta Monteiro, Ana Agua-Doce, Catarina F Almeida, Diogo Fonseca-Pereira, Henrique Veiga-Fernandes, Luis Graca
J Immunol | Published : 2015
Invariant NKT (iNKT) cell thymic development can lead to distinct committed effector lineages, namely NKT1, NKT2, and NKT17. However, following identification of IL-9-producing iNKT cells involved in mucosal inflammation, their development remains unaddressed. In this study, we report that although thymic iNKT cells from naive mice do not express IL-9, iNKT cell activation in the presence of TGF-β and IL-4 induces IL-9 secretion in murine and human iNKT cells. Acquisition of IL-9 production was observed in different iNKT subsets defined by CD4, NK1.1, and neuropilin-1, indicating that distinct functional subpopulations are receptive to IL-9 polarization. Transcription factor expression kinet..View full abstract
Awarded by Crohn's & Colitis Foundation of America