Journal article
IL-9 expression by invariant NKT cells is not imprinted during thymic development
M Monteiro, A Agua-Doce, CF Almeida, D Fonseca-Pereira, H Veiga-Fernandes, L Graca
Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2015
Abstract
Invariant NKT (iNKT) cell thymic development can lead to distinct committed effector lineages, namely NKT1, NKT2, and NKT17. However, following identification of IL-9-producing iNKT cells involved in mucosal inflammation, their development remains unaddressed. In this study, we report that although thymic iNKT cells from naive mice do not express IL-9, iNKT cell activation in the presence of TGF-β and IL-4 induces IL-9 secretion in murine and human iNKT cells. Acquisition of IL-9 production was observed in different iNKT subsets defined by CD4, NK1.1, and neuropilin-1, indicating that distinct functional subpopulations are receptive to IL-9 polarization. Transcription factor expression kinet..
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Awarded by Horizon 2020 Framework Programme
Funding Acknowledgements
This work was supported by Fundacao Para a Ciencia e Tecnologia, Portugal Grants PTDC/SAU-TOX/114424/2009 and HMSP-ICT/0034/2013 and the Novo Nordisk/European Foundation for the Study of Diabetes (to L.G.), as well as by grants from the Fundacao Para a Ciencia e Tecnologia, Portugal, the European Molecular Biology Organization, the European Research Council, and the U.S. National Blood Foundation (to H.V.-F.). A.A.-D., C.F.A., D.F.-P., and M.M. were supported by fellowships from the Fundacao Para a Ciencia e Tecnologia, Portugal.