Journal article

Regulation of the Germinal Center Reaction by Foxp3( ) Follicular Regulatory T Cells

Ivonne Wollenberg, Ana Agua-Doce, Andrea Hernandez, Catarina Almeida, Vanessa G Oliveira, Jose Faro, Luis Graca



Follicular helper T (T(FH)) cells participate in humoral responses providing selection signals to germinal center B cells. Recently, expression of CXCR5, PD-1, and the transcription factor Bcl-6 has allowed the identification of T(FH) cells. We found that a proportion of follicular T cells, with phenotypic characteristics of T(FH) cells and expressing Foxp3, are recruited during the course of a germinal center (GC) reaction. These Foxp3(+) cells derive from natural regulatory T cells. To establish the in vivo physiologic importance of Foxp3(+) follicular T cells, we used CXCR5-deficient Foxp3(+) cells, which do not have access to the follicular region. Adoptive cell transfers of CXCR5-defici..

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Awarded by Sudoe Grant

Awarded by Fundacao para a Ciencia e a Tecnologia (Portugal)

Awarded by Ministerio de Ciencia e Innovacion (Spain)

Awarded by European Union

Funding Acknowledgements

This work was supported by Sudoe Grant Immunonet-SOE1/1P1/E014 and Fundacao para a Ciencia e a Tecnologia (Portugal) Grant PTDC/SAU-IMU/120225/2010 (to L. G.), Ministerio de Ciencia e Innovacion (Spain) Grants SAF2007-63152 and HP2008-0018 (to J.F.), and People International Research Staff Exchange Scheme Grant GA-2008-230665 (7th Framework Program, European Union) (to J.F.).