PET staging of amyloidosis using striatum

BJ Hanseeuw; RA Betensky; EC Mormino; AP Schultz; J Sepulcre; JA Becker; HIL Jacobs; RF Buckley; MR LaPoint; P Vannini; NJ Donovan; JP Chhatwal; GA Marshall; KV Papp; RE Amariglio; DM Rentz; RA Sperling; KA Johnson

Journal article

PET staging of amyloidosis using striatum

BJ Hanseeuw, RA Betensky, EC Mormino, AP Schultz, J Sepulcre, JA Becker, HIL Jacobs, RF Buckley, MR LaPoint, P Vannini, NJ Donovan, JP Chhatwal, GA Marshall, KV Papp, RE Amariglio, DM Rentz, RA Sperling, KA Johnson

Alzheimer S and Dementia | Published : 2018

DOI: 10.1016/j.jalz.2018.04.011

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Abstract

Introduction: Amyloid positron emission tomography (PET) data are commonly expressed as binary measures of cortical deposition. However, not all individuals with high cortical amyloid will experience rapid cognitive decline. Motivated by postmortem data, we evaluated a three-stage PET classification: low cortical; high cortical, low striatal; and high cortical, high striatal amyloid; hypothesizing this model could better reflect Alzheimer's dementia progression than a model based only on cortical measures. Methods: We classified PET data from 1433 participants (646 normal, 574 mild cognitive impairment, and 213 AD), explored the successive involvement of cortex and striatum using 3-year foll..

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