Disease modeling and functional screening using engineered heart tissue
Richard J Mills, Holly K Voges, Enzo R Porrello, James E Hudson
CURRENT OPINION IN PHYSIOLOGY | ELSEVIER SCIENCE BV | Published : 2018
Recent advances in cardiac tissue engineering and pluripotent stem cell technologies are providing unprecedented access to human heart tissue with in vivo-like structural and functional properties. Engineered heart tissue (EHT) is emerging as a powerful technology platform for regenerative medicine, as well as for in vitro modeling of human physiological and pathophysiological processes. Here, we discuss the potential of EHT for studying cellular interactions within the heart and for modeling genetic and environmental causes of cardiovascular disease. In addition, we highlight the utility of EHT for drug screening and the identification of novel therapeutic modalities.
E.R.P. and J.E.H. are supported by fellowships and grants from the National Health and Medical Research Council of Australia, the National Heart Foundation, Stem Cells Australia, The University of Queensland and the Victorian Government's Operational Infrastructure Support Program.