TNF signalling via the TNF receptors mediates the effects of exercise on cognition-like behaviours
Julie A Morgan, Gaurav Singhal, Frances Corrigan, Emily J Jaehne, Magdalene C Jawahar, Bernhard T Baune
BEHAVIOURAL BRAIN RESEARCH | ELSEVIER SCIENCE BV | Published : 2018
BACKGROUND: Altered TNF levels are associated with cognitive impairment in depression, schizophrenia, bipolar disorder, and Alzheimer's disease (AD). Exercise improves cognition-like behaviours, reduces the expression of tumour necrosis factor alpha (TNF), and increases expression of the soluble TNF receptors soluble TNFR1 (sTNFR1) and sTNFR2. We suggest TNF and its receptors are involved in cognitive function and dysfunction, and investigate whether exercise mediates its effects on cognitive function via TNF and its receptors. METHODS: We utilised C57BL/6, TNF-/-, TNFR1-/-, and TNFR2-/- mice to compare exercise to non-exercise control groups to investigate whether exercise exerts its effect..View full abstract
Awarded by National Health and Medical Research Council grant (NHMRC)
This work was supported by a National Health and Medical Research Council grant (NHMRC) Grant (application 1043771 to BT. Baune), the Australian Postgraduate Award, The Ian Wilson Liberal Research Scholarship, and support from Mr I. B. Knowles, and Ms S. Saint-Saens to J. A. Morgan. Financial supporters had no role in any aspect of the work.