Journal article

Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium

Wouter J Peyrot, Sandra Van der Auwera, Yuri Milaneschi, Conor V Dolan, Pamela AF Madden, Patrick F Sullivan, Jana Strohmaier, Stephan Ripke, Marcella Rietschel, Michel G Nivard, Niamh Mullins, Grant W Montgomery, Anjali K Henders, Andrew C Heat, Helen L Fisher, Erin C Dunn, Enda M Byrne, Tracy A Air, Major Depressive, Bernhard T Baune Show all

BIOLOGICAL PSYCHIATRY | ELSEVIER SCIENCE INC | Published : 2018

Abstract

BACKGROUND: The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS × CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample. METHODS: Data were combined from 3024 MDD cases and 2741 control subjects from nine cohorts contributing to the MDD Working Group of the Psychiatric Genomics Consort..

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University of Melbourne Researchers

Grants

Awarded by Australian National Health and Medical Research Council


Awarded by Netherlands Organization for Scientific Research (MagW/ZonMW Grant)


Awarded by Spinozapremie Grant


Awarded by Geestkracht program


Awarded by Netherlands Bioinformatics Centre/BioAssist/RK


Awarded by European Science Foundation


Awarded by European Community's Seventh Framework Program


Awarded by European Network for Genetic and Genomic Epidemiology (ENGAGE)


Awarded by European Science Council (European Research Council Grant)


Awarded by National Institute of Mental Health


Awarded by National Health and Medical Research Council


Awarded by Federal Ministry of Education and Research


Awarded by German Research Foundation


Awarded by German Federal Ministry of Education and Research


Awarded by Royal Netherlands Academy of Science Professor Award


Awarded by UK Medical Research Council


Awarded by European Community's Seventh Framework Programme under the Marie Curie Industry-Academia Partnership and Pathways


Awarded by Macquarie University


Awarded by MRC


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Awarded by OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH


Funding Acknowledgements

This study was funded by the Australian National Health and Medical Research Council Grant Nos. 1078901 and 1087889 (to NRW) and Fellowship No. 1053639 (to EMB). The NESDA was funded by the Netherlands Organization for Scientific Research (MagW/ZonMW Grant Nos. 904-61-090, 985-10-002, 904-61-193, 480-04-004, 400-05-717, 912-100-20; Spinozapremie Grant No. 56-464-14192; Geestkracht program Grant No. 10-000-1002); the Center for Medical Systems Biology (NWO Genomics), Biobanking and Biomolecular Resources Research Infrastructure, VU Institutes for Health and Care Research and Neuroscience Campus Amsterdam, Netherlands Bioinformatics Centre/BioAssist/RK (Grant No. 2008.024); the European Science Foundation (Grant No. EU/QLRT-2001-01254); the European Community's Seventh Framework Program (Grant No. FP7/2007-2013); European Network for Genetic and Genomic Epidemiology (ENGAGE) (Grant No. HEALTH-F4-2007-201413); and the European Science Council (European Research Council Grant No. 230374). Genotyping was funded in part by the Genetic Association Information Network of the Foundation for the US National Institutes of Health, and analysis was supported by grants from Genetic Association Information Network and the National Institute of Mental Health (Grant No. MH081802). COFAMS was supported by a grant from the National Health and Medical Research Council (Grant No. APP 1060524 to BTB). SHIP is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (Grant Nos. 01ZZ9603, 01ZZ0103, and 01ZZ0403), the Ministry of Cultural Affairs, and the Social Ministry of the Federal State of Mecklenburg-West Pomerania. Genome-wide data analyses in SHIP have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany, and the Federal State of Mecklenburg-West Pomerania. Genome-wide genotyping in SHIP-TREND-0 was supported by the Federal Ministry of Education and Research (Grant No. 03ZIK012). This work was also funded by the German Research Foundation (Grant No. GR 1912/5-1). In addition, this work was supported by the German Federal Ministry of Education and Research within the framework of the e:Med research and funding concept (Integrament; Grant No. 01ZX1314E). DIB received Royal Netherlands Academy of Science Professor Award PAH/6635. MR received funding from the German Federal Ministry of Education and Research within the context of the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders; Grant No. 01ZX1314G). The German Research Foundation within the context of Forschergruppe 2107 awarded Grant Nos. RI908/11-1 (to MR) and WI 3439/3-1 (to SHW). This report represents independent research partially funded by the National Institute for Health Research Biomedical Research Centre at South London and Maudsley National Health Service Foundation Trust and King's College London. The RADIANT studies were funded by a joint grant from the UK Medical Research Council (Grant No. G0701420) and GlaxoSmithKline and by the National Institute for Health Research Biomedical Research Centre for Mental Health at South London and Maudsley National Health Service Foundation Trust and Institute of Psychiatry, Psychology, and Neuroscience, King's College London. The European Community's Seventh Framework Programme under the Marie Curie Industry-Academia Partnership and Pathways awarded Grant No. 286213 (to NM and CML). The National Institute of Mental Health provided Grant No. 1K01MH102403 (to ECD).Macquarie University provided Fellows Award No. MQ14F40 (to HLF).