Journal article

Cognitive impairment as measured by the THINC-integrated tool (THINC-it): Association with psychosocial function in major depressive disorder

Danielle S Cha, Nicole E Carmona, Mehala Subramaniapillai, Rodrigo B Mansur, Yena Lee, Jae Hon Lee, JungGoo Lee, Joshua D Rosenblat, Margarita Shekotikhina, Caroline Park, Carola Rong, Tracy L Greer, Raymond Lam, Bernhard T Baune, John Harrison, Roger S McIntyre

Journal of Affective Disorders | ELSEVIER SCIENCE BV | Published : 2017

Abstract

BACKGROUND: Psychosocial impairment represents an important treatment target in major depressive disorder (MDD). The majority of patients with MDD do not regain premorbid levels of psychosocial functioning despite the resolution of core depressive symptoms. This study aimed to investigate the respective effects of cognitive function and depression severity on impaired psychosocial function in MDD. METHODS: Adults aged 18-65 with moderate-to-severe MDD (n = 100) and age-, sex-, and education-matched healthy controls participated in a cross-sectional study validating the THINC-integrated tool (THINC-it), a cognitive screening tool comprised of objective and subjective measures of cognitive fun..

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University of Melbourne Researchers