Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

SH Witt; F Streit; M Jungkunz; J Frank; S Awasthi; CS Reinbold; J Treutlein; F Degenhardt; AJ Forstner; S Heilmann-Heimbach; L Dietl; CE Schwarze; D Schendel; J Strohmaier; A Abdellaoui; R Adolfsson; TM Air; H Akil; M Alda; N Alliey-Rodriguez; OA Andreassen; G Babadjanova; NJ Bass; M Bauer; BT Baune; F Bellivier; S Bergen; A Bethell; JM Biernacka; DHR Blackwood; MP Boks; DI Boomsma; AD Børglum; M Borrmann-Hassenbach; P Brennan; M Budde; HN Buttenschøn; EM Byrne; P Cervantes; TK Clarke; N Craddock; C Cruceanu; D Curtis; PM Czerski; U Dannlowski; T Davis; EJC de Geus; A Di Florio; S Djurovic; E Domenici; HJ Edenberg; B Etain; SB Fischer; L Forty; C Fraser; MA Frye; JM Fullerton; K Gade; ES Gershon; I Giegling; SD Gordon; K Gordon-Smith; HJ Grabe; EK Green; TA Greenwood; M Grigoroiu-Serbanescu; J Guzman-Parra; LS Hall; M Hamshere; J Hauser; M Hautzinger; U Heilbronner; S Herms; S Hitturlingappa; P Hoffmann; P Holmans; JJ Hottenga; S Jamain; I Jones; LA Jones; A Juréus; RS Kahn; J Kammerer-Ciernioch; G Kirov; S Kittel-Schneider; S Kloiber; SV Knott; M Kogevinas; M Landén; M Leber; M Leboyer; QS Li; J Lissowska; S Lucae; NG Martin; F Mayoral-Cleries; SL McElroy; AM McIntosh; JD McKay; A McQuillin

Journal article

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

SH Witt, F Streit, M Jungkunz, J Frank, S Awasthi, CS Reinbold, J Treutlein, F Degenhardt, AJ Forstner, S Heilmann-Heimbach, L Dietl, CE Schwarze, D Schendel, J Strohmaier, A Abdellaoui, R Adolfsson, TM Air, H Akil, M Alda, N Alliey-Rodriguez Show all

Translational Psychiatry | NATURE PUBLISHING GROUP | Published : 2017

DOI: 10.1038/tp.2017.115

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Abstract

Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case-control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR an..

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University of Melbourne Researchers

Bernhard Baune Author

Grants

Awarded by European Commission

Funding Acknowledgements

We thank all patients and control subjects for their participation. We thank the KFO 256 workgroup of the CIMH, and Bipolar Disorder Working Group-, the Major Depression Working Group-and the Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC-BIP, PGC-MDD, PGC-SCZ) for providing access to the relevant data. The Romanian sample was funded by UEFISCDI, Romania, grant no. 89/2012 to MGS. The CoLaus|PsyCoLaus study was and is supported by research grants from GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne and the Swiss National Science Foundation (grants 3200B0-105993, 3200B0-118308, 33CSCO-122661, 33CS30-139468 and 33CS30-148401). The study was supported by the German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under the auspices of the e:Med Programme (grant 01ZX1314A to MMN and SC; grant 01ZX1314G to MR). The study was supported by the German Research Foundation (DFG; grant FOR2107; RI908/11-1 to MR; WI3429/3-1 to SHW; NO246/10-1 to MMN; DA1151/5-1 to UD; KFO 256 BO 1487/12-1 to MB;. SFB 779 TP A08 to BHS).