Journal article
Polygenic risk for depression and the neural correlates of working memory in healthy subjects
D Yüksel, B Dietsche, AJ Forstner, SH Witt, R Maier, M Rietschel, C Konrad, MM Nöthen, U Dannlowski, BT Baune, T Kircher, A Krug
Progress in Neuro Psychopharmacology and Biological Psychiatry | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017
Abstract
Introduction Major depressive disorder (MDD) patients show impairments of cognitive functioning such as working memory (WM), and furthermore alterations during WM-fMRI tasks especially in frontal and parietal brain regions. The calculation of a polygenic risk score (PRS) can be used to describe the genetic influence on MDD, hence imaging genetic studies aspire to combine both genetics and neuroimaging data to identify the influence of genetic factors on brain functioning. We aimed to detect the effect of MDD-PRS on brain activation during a WM task measured with fMRI and expect healthy individuals with a higher PRS to be more resembling to MDD patients. Method In total, n = 137 (80 men, 57 w..
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Awarded by Bundesministerium für Bildung und Forschung
Funding Acknowledgements
[ "This work was supported by grants from the German Research Foundation (DFG, grant no. KR 3822/2-1 to AK, grant no. DA 1151/5-1 to UD, FOR 2107 NO 246/10-1 to MMN, FOR 2107 RI 908/11-1 to MR, and FOR 2107, grant no. KI 588/14-1), a grant by the University Medical Center Giessen and Marburg (UKGM, grant no. 11/2010 MR) and the Von-Behring-Rntgen-Foundation (grant no. 61-0030).", "This work was also supported by the German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under the auspices of the e:Med Programme (grant 01ZX1314A to MMN, grant 01ZX1314G to MR). MMN is a member of the DFG-funded Excellence-Cluster ImmunoSensation." ]