Journal article

Whole-genome single nucleotide variant distribution on genomic regions and its relationship to major depression

Chenglong Yu, Bernhard T Baune, Julio Licinio, Ma-Li Wong

Psychiatry Research | ELSEVIER IRELAND LTD | Published : 2017

Abstract

Recent advances in DNA technologies have provided unprecedented opportunities for biological and medical research. In contrast to current popular genotyping platforms which identify specific variations, whole-genome sequencing (WGS) allows for the detection of all private mutations within an individual. Major depressive disorder (MDD) is a chronic condition with enormous medical, social and economic impacts. Genetic analysis, by identifying risk variants and thereby increasing our understanding of how MDD arises, could lead to improved prevention and the development of new and more effective treatments. Here we investigated the distributions of whole-genome single nucleotide variants (SNVs) ..

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University of Melbourne Researchers

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Awarded by NHMRC


Awarded by NIH


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

The authors have been supported by Grants NHMRC APP1051931 (MLW), NHMRC APP1060524 (BTB), and NIH Grant GM61394 (JL and MLW), and institutional funds from the South Australian Health and Medical Research Institute.