Structural brain changes and all-cause mortality in the elderly population—the mediating role of inflammation

U Hanning; A Roesler; A Peters; K Berger; BT Baune

Journal article

Structural brain changes and all-cause mortality in the elderly population—the mediating role of inflammation

U Hanning, A Roesler, A Peters, K Berger, BT Baune

Age | SPRINGER | Published : 2016

DOI: 10.1007/s11357-016-9951-9

Abstract

While MRI brain changes have been related to mortality during ageing, the role of inflammation in this relationship remains poorly understood. Hence, this study aimed to investigate the impact of MRI changes on all-cause mortality and the mediating role of cytokines. All-cause mortality was evaluated in 268 community dwelling elderly (age 65–83 years) in the MEMO study (Memory and Morbidity in Augsburg elderly). MRI markers of brain atrophy and cerebral small vessel disease (SVD), C-reactive protein (CRP) and a panel of cytokines in serum were assessed. Cox proportional hazard models were used to estimate the association of MRI changes with survival over 9 years. Regression models were used ..

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University of Melbourne Researchers

Bernhard Baune Author

Grants

Awarded by German Research Society (DFG)

Awarded by Federal German Ministry of Education and Research (BMBF)

Funding Acknowledgements

The MEMO study is supported by the German Research Society (DFG, grant: BE1996/1-1). Data assessment was carried out within the framework of the Cooperative Health Research in the Augsburg Region (KORA). This study was supported by the Federal German Ministry of Education and Research (BMBF, grant 01ER1205). Dr. U. Hanning receives a research grant of the Medical Faculty of the University of Muenster.