Journal article

Cytokine levels in major depression are related to childhood trauma but not to recent stressors

Laura Grosse, Oliver Ambree, Silke Joergens, M Catharine Jawahar, Gaurav Singhal, David Stacey, Volker Arolt, Bernhard T Baune

PSYCHONEUROENDOCRINOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2016

Abstract

BACKGROUND: Major depressive disorder (MDD) is a stress-related psychiatric disorder. A subgroup of MDD patients is characterized by increased inflammatory activation. We aimed to investigate whether increased inflammation particularly occurs in MDD patients with a history of stressful early or later life experiences. METHODS: Serum levels of tumor necrosis factor alpha (TNF-α) and interleukin (IL)-6 were determined in N=214 MDD patients and N=180 healthy controls (HC). Childhood trauma (Childhood Trauma Questionnaire - CTQ), adverse life events of the past 12 months (List of Threatening Experiences Questionnaire - LTE-Q), and perceived stress in the past month (Perceived Stress Scale - PSS)..

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University of Melbourne Researchers