Genetic variants associated with response to lithium treatment in bipolar disorder: A genome-wide association study

Grants

Funding Acknowledgements

Deutsche Forschungsgemeinschaft, National Institute of Mental Health Intramural Research Program.r We are greatly indebted to all the study participants without whom this research would not have been possible. We thank the members of our Scientific Advisory Board for critical input over the course of the project. This work was in part funded by the Deutsche Forschungsgemeinschaft (DFG; grant no RI 908/7-1; grant FOR2107, RI 908/11-1 to Marcella Rietschel, Michael Bauer, and Thomas G Schulze, NO 246/10-1 to MMN) and the Intramural Research Program of the National Institute of Mental Health (ZIA-MH00284311; NCT00001174). The genotyping was in part funded by the German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under the auspices of the e:Med Programme (grants awarded to TGS, MR, and MMN). OG, AP, TSt, MB, AR, and TGS received support from the German Federal Ministry of Education and Research (BMBF) within the framework of the BipolLife network. MMN received support from the Alfried Krupp von Bohlen und Halbach-Stiftung. Franziska Degenhardt received support from the BONFOR Programme of the University of Bonn, Germany. EZR received funding from the Land Steiermark as principal investigator. MS received funds from the Swedish Research Council, Swedish Brain Foundation and funds from Karolinska Institutet and Karolinska University Hospital. Some data and biomaterials were collected as part of eleven projects (Study 40) that participated in the National Institute of Mental Health (NIMH) Bipolar Disorder Genetics Initiative. From 2003-07, the principal investigators and co-investigators were: Indiana University, Indianapolis, IN, R01 MH59545 (John Nurnberger, Marvin J Miller, Elizabeth S Bowman, N Leela Rau, P Ryan Moe, Nalini Samavedy, Rif El-Mallakh [University of Louisville], Husseini Manji [Johnson and Johnson], Debra A Glitz [Wayne State University], Eric T Meyer [Oxford University, UK], Carrie Smiley, Tatiana Foroud, Leah Flury, Danielle M Dick [Virginia Commonwealth University], Howard Edenberg); Washington University, St Louis, MO, R01 MH059534 (John Rice, Theodore Reich, Allison Goate, Laura Bierut [K02 DA21237]); Johns Hopkins University, Baltimore, R01 MH59533 (Melvin McInnis, J Raymond DePaulo Jr, Dean F MacKinnon, Francis M Mondimore, James B Potash, Peter P Zandi, Dimitrios Avramopoulos, Jennifer Payne); University of Pennsylvania, PA, R01 MH59553 (Wade Berrettini); University of California at San Francisco, CA, R01 MH60068 (William Byerley, Sophia Vinogradov); University of Iowa, IA, R01 MH059548 (William Coryell, Raymond Crowe); University of Chicago, IL, R01 MH59535 (Elliot Gershon, Judith Badner, Francis McMahon, Chunyu Liu, Alan Sanders, Maria Caserta, Steven Dinwiddie, Tu Nguyen, Donna Harakal); University of California at San Diego, CA, R01 MH59567 (John Kelsoe, Rebecca McKinney); Rush University, IL, R01 MH059556 (William Scheftner, Howard M Kravitz, Diana Marta, Annette Vaughn-Brown, Laurie Bederow); and NIMH Intramural Research Program, Bethesda, 1Z01MH002810-01 (Francis J McMahon, Layla Kassem, PsyD, Sevilla Detera-Wadleigh, Lisa Austin, Dennis L Murphy [Howard University], William B Lawson, Evarista Nwulia, Maria Hipolito). This work was supported by the NIH grants P50CA89392 from the National Cancer Institute and 5K02DA021237 from the National Institute of Drug Abuse. The Canadian part of the study was supported by a grant #64410 from the Canadian Institutes of Health Research to MAl.r r We wish to thank Joanne Petite and Giselle Kraus for assistance with data collection.r Collection and phenotyping of the Australian UNSW sample, by PBM, PRS, JMF, and AW, was funded by an Australian NHMRC Program Grant (No. 1037196). The collection of the Barcelona sample was supported by the Centro de Investigacion en Red de Salud Mental (CIBERSAM) IDIBAPS (grant numbers PI080247, PI1200906, PI12/00018), and Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement (2014SGR1636 and 2014SGR398). J-MA and AD were supported by the Swiss National Science Foundation (grant number 32003B_125469 and NCCR Synapsy). DC was supported by a Medical Research Council Clinician Scientist Fellowship Award (MR/L006642/1). LF was supported by the Swedish Research Council (grant no 523-2011-3807). MG-S was supported by UEFISCDI, Romania, grant no 89/2012. P-HK was funded by the Taiwan Ministry of Science and Technology (grant no MST 99-2314-B-002-140-MY3 and 102-2314-B-002-117-MY3). CALJ was funded by the "Estrategia de Sostenibilidad 2014-2015" program of the University of Antioquia. TN was supported by the Ministry of Health of the Czech Republic (grant no IGA NT13891). JBP was supported by the Reuben Stoltzfus Bipolar Research Fund and with SKT received funding from the James Wah Fund and Project MATCH. TGS and UH received support from the Dr-Lisa-Oehler-Foundation (Kassel, Germany). AS has a postdoctoral fellowship funded by the Sardinia Regional Government POR Sardegna FSE Operational Program of the Autonomous Region of Sardinia, European Social Fund 2007-2013-Axis IV Human Resources, Objective l.3, Line of Activity l.3.1. NRW was funded by Australian NHMRC Fellowships 613602 and 1078901. MMan is now a resident in the psychiatry training program at the Section of Psychiatry, Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Cagliari, Italy. This study used the high-performance computational capabilities of the Biowulf Linux cluster at the National Institutes of Health, Bethesda, MD. Genotyping for part of the Swedish sample was funded by the Stanley Center for Psychiatric Research at the Broad Institute.