Journal article

Altered resting-state functional connectivity in late-life depression: A cross-sectional study

Harris A Eyre, Hongyu Yang, Amber M Leaver, Kathleen Van Dyk, Prabha Siddarth, Natalie St Cyr, Katherine Narr, Linda Ercoli, Bernhard T Baune, Helen Lavretsky

JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER SCIENCE BV | Published : 2016

Abstract

BACKGROUND: Disrupted brain connectivity is implicated in the pathophysiology of late-life depression (LLD). There are few studies in this area using resting-state functional magnetic resonance imaging (rs-fMRI). In this pilot case-control study, we compare rs-fMRI data between age-matched depressed and non-depressed older adults. METHODS: Older participants (≥55 years) with current major depressive disorder (MDD) were recruited to participate in an ongoing study of LLD, and were compared to the age-matched, non-depressed controls. Rs-fMRI data were collected using a 3-Tesla MRI system. In this study, a data-driven approach was chosen and an independent component analysis (ICA) was performed..

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University of Melbourne Researchers