Metabolic burden and disease and mortality risk associated with impaired fasting glucose in elderly adults

Abstract

Objectives To examine whether impaired fasting glucose (IFG) represents an intermediary condition between normal fasting glucose and diabetes mellitus and, specifically, whether elderly adults with IFG have higher disease burden, cardiovascular risk, and systemic inflammation and higher 2-year mortality and incident disease. Design Prospective observational study. Setting Population-derived cohort. Participants Individuals with a mean age of 78.6 ± 4.7 (N = 945). Measurements Disease was ascertained using a standardized questionnaire at baseline and 2 years. Fasting metabolic, inflammatory, and oxidative metabolism markers were measured. Disease prevalence, cardiovascular risk, and biochemic..