Journal article

The Relationship of Serum Macrophage Inhibitory Cytokine-1 Levels with Gray Matter Volumes in Community-Dwelling Older Individuals

Jiyang Jiang, Wei Wen, David A Brown, John Crawford, Anbupalam Thalamuthu, Evelyn Smith, Samuel N Breit, Tao Liu, Wanlin Zhu, Henry Brodaty, Bernhard T Baune, Julian N Trollor, Perminder S Sachdev

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2015


Using circulating inflammatory markers and magnetic resonance imaging (MRI), recent studies have associated inflammation with brain volumetric measures. Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) is a divergent transforming growth factor - beta (TGF-β) superfamily cytokine. To uncover the underlying mechanisms of the previous finding of a negative association between MIC-1/GDF15 serum levels and cognition, the present study aimed to examine the relationship of circulating MIC-1/GDF15 levels with human brain gray matter (GM) volumes, in a community-dwelling sample aged 70-90 years over two years (Wave 1: n = 506, Wave 2: n = 327), of which the age-related brain atrophy had been previously..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Australian Research Council

Funding Acknowledgements

This research was supported by the National Health and Medical Research Council (NHMRC,, NHMRC Program Grant ID 350833, NHMRC Project Grant ID 510175 and NHMRC Project Grant ID 510124), and the Australian Research Council (, DP0774213, DP0773584 and LP0669645). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.