Journal article
The Relationship of Serum Macrophage Inhibitory Cytokine-1 Levels with Gray Matter Volumes in Community-Dwelling Older Individuals
Jiyang Jiang, Wei Wen, David A Brown, John Crawford, Anbupalam Thalamuthu, Evelyn Smith, Samuel N Breit, Tao Liu, Wanlin Zhu, Henry Brodaty, Bernhard T Baune, Julian N Trollor, Perminder S Sachdev
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2015
Abstract
Using circulating inflammatory markers and magnetic resonance imaging (MRI), recent studies have associated inflammation with brain volumetric measures. Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) is a divergent transforming growth factor - beta (TGF-β) superfamily cytokine. To uncover the underlying mechanisms of the previous finding of a negative association between MIC-1/GDF15 serum levels and cognition, the present study aimed to examine the relationship of circulating MIC-1/GDF15 levels with human brain gray matter (GM) volumes, in a community-dwelling sample aged 70-90 years over two years (Wave 1: n = 506, Wave 2: n = 327), of which the age-related brain atrophy had been previously..
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Awarded by National Health and Medical Research Council (NHMRC)
Awarded by Australian Research Council
Funding Acknowledgements
This research was supported by the National Health and Medical Research Council (NHMRC, https://www.nhmrc.gov.au/, NHMRC Program Grant ID 350833, NHMRC Project Grant ID 510175 and NHMRC Project Grant ID 510124), and the Australian Research Council (http://www.arc.gov.au/, DP0774213, DP0773584 and LP0669645). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.