The relationship of serum macrophage inhibitory cytokine - 1 levels with gray matter volumes in community-dwelling older individuals

J Jiang; W Wen; DA Brown; J Crawford; A Thalamuthu; E Smith; SN Breit; T Liu; W Zhu; H Brodaty; BT Baune; JN Trollor; PS Sachdev

Journal article

The relationship of serum macrophage inhibitory cytokine - 1 levels with gray matter volumes in community-dwelling older individuals

J Jiang, W Wen, DA Brown, J Crawford, A Thalamuthu, E Smith, SN Breit, T Liu, W Zhu, H Brodaty, BT Baune, JN Trollor, PS Sachdev

Plos One | PUBLIC LIBRARY SCIENCE | Published : 2015

DOI: 10.1371/journal.pone.0123399

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Abstract

Using circulating inflammatory markers and magnetic resonance imaging (MRI), recent studies have associated inflammation with brain volumetric measures. Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) is a divergent transforming growth factor - beta (TGF-β) superfamily cytokine. To uncover the underlying mechanisms of the previous finding of a negative association between MIC-1/GDF15 serum levels and cognition, the present study aimed to examine the relationship of circulating MIC-1/GDF15 levels with human brain gray matter (GM) volumes, in a community-dwelling sample aged 70-90 years over two years (Wave 1: n = 506, Wave 2: n = 327), of which the age-related brain atrophy had been previously..

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University of Melbourne Researchers

Bernhard Baune Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This research was supported by the National Health and Medical Research Council (NHMRC, https://www.nhmrc.gov.au/, NHMRC Program Grant ID 350833, NHMRC Project Grant ID 510175 and NHMRC Project Grant ID 510124), and the Australian Research Council (http://www.arc.gov.au/, DP0774213, DP0773584 and LP0669645). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.