Long-term omega-3 supplementation modulates behavior, hippocampal fatty acid concentration, neuronal progenitor proliferation and central TNF-alpha expression in 7 month old unchallenged mice
Trent Grundy, Catherine Toben, Emily J Jaehne, Frances Corrigan, Bernhard T Baune
Frontiers in Cellular Neuroscience | FRONTIERS MEDIA SA | Published : 2014
Dietary polyunsaturated fatty acid (PUFA) manipulation is being investigated as a potential therapeutic supplement to reduce the risk of developing age-related cognitive decline (ARCD). Animal studies suggest that high omega (Ω)-3 and low Ω-6 dietary content reduces cognitive decline by decreasing central nervous system (CNS) inflammation and modifying neuroimmune activity. However, no previous studies have investigated the long term effects of Ω-3 and Ω-6 dietary levels in healthy aging mice leaving the important question about the preventive effects of Ω-3 and Ω-6 on behavior and underlying molecular pathways unaddressed. We aimed to investigate the efficacy of long-term Ω-3 and Ω-6 PUFA d..View full abstract
This study was financially supported by the Neuroimmunology Research group of the University of Adelaide. The authors thank D. Apps from WAS for analyzing the free fatty acids, C. Jawahar for assistance with behavioral and feed protocols and thank Z. Sarnyai for helpful discussions on the topic of this manuscript.