Journal article

Inflammasonnes in neuroinflammation and changes in brain function: a focused review

Gaurav Singhal, Emily J Jaehne, Frances Corrigan, Catherine Toben, Bernhard T Baune

Frontiers in Neuroscience | FRONTIERS MEDIA SA | Published : 2014

Abstract

Recent literature has pointed to the existence of inflammasome-mediated inflammatory pathways in central nervous system (CNS) disorders and associated changes in behavior. Neuroinflammation, which is an innate immune response in the CNS against harmful and irritable stimuli such as pathogens and metabolic toxic waste, as well as to chronic mild stress, is mediated by protein complexes known as inflammasomes. Inflammasomes activate pro-inflammatory caspases 1 and 5, which then cleave the precursor forms of pro-inflammatory cytokines IL-1β, IL-18, and IL-33 into their active forms. These pro-inflammatory cytokines have been shown to promote a variety of innate immune processes associated with ..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council Australia


Funding Acknowledgements

The presented work is supported by the National Health and Medical Research Council Australia (APP 1043771 to Bernhard T. Baune). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.