Journal article
Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment
G Singhal, EJ Jaehne, F Corrigan, BT Baune
Frontiers in Cellular Neuroscience | FRONTIERS MEDIA SA | Published : 2014
Open access
Abstract
Recent studies on environmental enrichment (EE) have shown cytokines, cellular immune components [e.g., T lymphocytes, natural killer (NK) cells], and glial cells in causal relationship to EE in bringing out changes to neurobiology and behavior. The purpose of this review is to evaluate these neuroimmune mechanisms associated with neurobiological and behavioral changes in response to different EE methods. We systematically reviewed common research databases. After applying all inclusion and exclusion criteria, 328 articles remained for this review. Physical exercise (PE), a form of EE, elicits anti-inflammatory and neuromodulatory effects through interaction with several immune pathways incl..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The presented work is supported by the National Health and Medical Research Council Australia (APP 1043771 to Bernhard T. Baune). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.