Journal article

Knockout of CXCR5 increases the population of immature neural cells and decreases proliferation in the hippocampal dentate gyrus

Michael J Stuart, Frances Corrigan, Bernhard T Baune

Journal of Neuroinflammation | BIOMED CENTRAL LTD | Published : 2014

Abstract

BACKGROUND: The process of neurogenesis in which new neurons are generated by proliferation and differentiation of neural stem/progenitor cells (NSCs/NPCs) has been a topic of intensive recent investigation. Investigations of the factors which regulate this process have recently begun to include immune factors including immune cells and cytokines, however the class of immune proteins designated as chemokines have been relatively neglected. Increasing evidence for novel brain-specific mechanisms of chemokines beyond their classical chemotactic functions has suggested that they may play a role in the regulation of NSC/NPC biology. METHODS: We have investigated the role of the chemokine recepto..

View full abstract

University of Melbourne Researchers