Journal article
Maternal separation modifies behavioural and neuroendocrine responses to stress in CCR7 deficient mice
EL Harrison, EJ Jaehne, MC Jawahar, F Corrigan, BT Baune
Behavioural Brain Research | ELSEVIER SCIENCE BV | Published : 2014
Abstract
Alterations in immune function of various humoral and cellular factors, including chemokines, secondary to early stress may play a role in the enhanced vulnerability to psychiatric conditions in those with a history of childhood adversity. C57BL/6 (WT) mice and mice deficient for the chemokine receptor type 7 (CCR7-/-) were used to determine the effects of maternal separation on a range of behaviours and the biological stress response. Unpredictable maternal separation (MS) was conducted for 3h daily from postnatal day 1 to 14, with subsequent behavioural testing at 10 weeks of age. Corticosterone was quantified in 11-week-old mice. Maternally separated (MS) CCR7-/-, but not WT mice, display..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study is supported by the National Health and Medical Research Council Australia (APP1003788 to BTB). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We would also like to thank Trent Grundy, Michael Stuart, Catherine Toben and Marie lou Camara from the Baune Lab for assistance with conducting the experimental work.