Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain
Bernhard T Baune, Carsten Konrad, Dominik Grotegerd, Thomas Suslow, Eva Birosova, Patricia Ohrmann, Jochen Bauer, Volker Arolt, Walter Heindel, Katharina Domschke, Sonja Schoening, Astrid V Rauch, Christina Uhlmann, Harald Kugel, Udo Dannlowski
Journal of Neuroinflammation | BMC | Published : 2012
BACKGROUND: Cytokines such as interleukin 6 (IL-6) have been implicated in dual functions in neuropsychiatric disorders. Little is known about the genetic predisposition to neurodegenerative and neuroproliferative properties of cytokine genes. In this study the potential dual role of several IL-6 polymorphisms in brain morphology is investigated. METHODOLOGY: In a large sample of healthy individuals (N = 303), associations between genetic variants of IL-6 (rs1800795; rs1800796, rs2069833, rs2069840) and brain volume (gray matter volume) were analyzed using voxel-based morphometry (VBM). Selection of single nucleotide polymorphisms (SNPs) followed a tagging SNP approach (e.g., Stampa algorigt..View full abstract
Awarded by Innovative Medizinische Forschung (IMF) of the Medical Faculty of Munster
Awarded by Interdisziplinares Zentrum fur Klinische Forschung (IZKF) of the Medical Faculty of Munster
Awarded by Rolf-Dierichs-Stiftung, Germany
The study was supported by grants of Innovative Medizinische Forschung (IMF) of the Medical Faculty of Munster (IMF DA120309 to UD, IMF DA211012 to UD, IMF DA111107 to UD, and IMF AR510403 to VA), Interdisziplinares Zentrum fur Klinische Forschung (IZKF) of the Medical Faculty of Munster (IZKF FG04 to CK), and Rolf-Dierichs-Stiftung (ZUW80037 to UD), Germany.KD has received speaker fees from Pfizer, Lilly, and Bristol-Myers Squibb; she has been a consultant for Johnson & Johnson and has received funding by Astra Zeneca. All other authors declare no conflicts of interest.