Journal article

Microglia: An Interface between the Loss of Neuroplasticity and Depression

Gaurav Singhal, Bernhard T Baune

Frontiers in Cellular Neuroscience | FRONTIERS MEDIA SA | Published : 2017

Abstract

Depression has been widely accepted as a major psychiatric disease affecting nearly 350 million people worldwide. Research focus is now shifting from studying the extrinsic and social factors of depression to the underlying molecular causes. Microglial activity is shown to be associated with pathological conditions, such as psychological stress, pathological aging, and chronic infections. These are primary immune effector cells in the CNS and regulate the extensive dialogue between the nervous and the immune systems in response to different immunological, physiological, and psychological stressors. Studies have suggested that during stress and pathologies, microglia play a significant role i..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council Australia (APP)


Funding Acknowledgements

The presented work is supported by the National Health and Medical Research Council Australia (APP 1043771 to BB). The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.