Genetic overlap between depression and cardiometabolic disorders

Abstract

Depression and major cardiometabolic disorders (in this chapter, cardiometabolic disorders refer to the cardiovascular diseases, metabolic disorders, and associated risk factors) are highly heritable, i.e., they are caused by a combination of genetic and environmental factors. Moreover, there are genetic coheritabilities (genetic correlations) in these disorders suggesting the influence of common genes and shared biological pathways between them. Several candidate gene studies performed so far have identified risk-associated genes for depression, cardiovascular, and/or metabolic diseases. Besides, meta-analysis of genome-wide association (meta-GWA) studies reported a number of single nucleot..