Pharmacoepigenetics of depression: no major influence of MAO-A DNA methylation on treatment response
Katharina Domschke, Nicola Tidow, Kathrin Schwarte, Christiane Ziegler, Klaus-Peter Lesch, Juergen Deckert, Volker Arolt, Peter Zwanzger, Bernhard T Baune
JOURNAL OF NEURAL TRANSMISSION | SPRINGER WIEN | Published : 2015
The monoamine oxidase A (MAO-A) gene has been suggested to be involved in the pathogenesis as well as the pharmacological treatment of major depressive disorder. In the present analysis, for the first time a pharmacoepigenetic approach was applied investigating the influence of DNA methylation patterns in the MAO-A regulatory and exon1/intron1 region on antidepressant treatment response. 94 patients of Caucasian descent with major depressive disorder (f = 61; DSM-IV) were analyzed for DNA methylation status at 43 MAO-A CpG sites via direct sequencing of sodium bisulfite treated DNA extracted from blood cells. Patients were also genotyped for the functional MAO-A VNTR. Clinical response to an..View full abstract
Awarded by Deutsche Forschungsgemeinschaft (DFG)
The present project was supported by the Doktor Robert Pfleger Stiftung and the Deutsche Forschungsgemeinschaft (DFG), SFB-TRR-58, project C02 (to KD, KPL and JD) as well as A05 (to KPL). We gratefully acknowledge the clinical support by Tilmann Roehrs and Jorn Lewin.