Journal article

Serotonin Transporter Gene Methylation is Associated With Hippocampal Gray Matter Volume

Udo Dannlowski, Harald Kugel, Ronny Redlich, Adriane Halik, Ilona Schneider, Nils Opel, Dominik Grotegerd, Kathrin Schwarte, Christiane Schettler, Oliver Ambree, Stephan Rust, Katharina Domschke, Volker Arolt, Walter Heindel, Bernhard T Baune, Thomas Suslow, Weiqi Zhang, Christa Hohoff

HUMAN BRAIN MAPPING | WILEY | Published : 2014

Abstract

BACKGROUND: The serotonin transporter (5-HTT) and the 5-HTTLPR/rs25531 polymorphisms in its gene (SLC6A4) have been associated with depression, increased stress-response, and brain structural alterations such as reduced hippocampal volumes. Recently, epigenetic processes including SLC6A4 promoter methylation were shown to be affected by stress, trauma, or maltreatment and are regarded to be involved in the etiology of affective disorders. However, neurobiological correlates of SLC6A4 promoter methylation have never been studied or compared to genotype effects by means of human neuroimaging hitherto METHODS: Healthy subjects were recruited in two independent samples (N = 94, N = 95) to obtain..

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University of Melbourne Researchers