Journal article

Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training

Yorgi Mavros, Shelley Kay, Kylie A Simpson, Michael K Baker, Yi Wang, Ren R Zhao, Jacinda Meiklejohn, Mike Climstein, Anthony J O'Sullivan, Nathan de Vos, Bernhard T Baune, Steven N Blair, David Simar, Kieron Rooney, Nalin A Singh, Maria A Fiatarone Singh

Journal of Cachexia, Sarcopenia and Muscle | WILEY | Published : 2014


BACKGROUND: Reductions in skeletal muscle mass and increased adiposity are key elements in the aging process and in the pathophysiology of several chronic diseases. Systemic low grade inflammation associated with obesity has been shown to accelerate the age-related decline in skeletal muscle. The aim of this investigation was to determine the effects of 12 months of progressive resistance training (PRT) on systemic inflammation, and whether reductions in systemic inflammation were associated with changes in body composition. We hypothesized that reductions in systemic inflammation following 12 months of PRT in older adults with type 2 diabetes would be associated with reductions in adiposity..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

We would like to thank Freshwater Health and Fitness for the use of their gym facilities, Keiser Sports Health, Ltd. for donations of resistance training equipment, and participants for their generosity of time and spirit. The Graded Resistance Exercise and Type 2 Diabetes in Older adults (GREAT2DO) study was funded by project grant # 512381 from the National Health and Medical Research Council (NHMRC), and grants from The Australian Diabetes Society and Diabetes Australia. Y. Mavros was supported by the Australian Postgraduate Award Scholarship. Y. Wang was supported by University of Sydney International Postgraduate Research Scholarship. The authors of this manuscript certify that they comply with the ethical guidelines for authorship and publishing in the Journal of Cachexia, Sarcopenia, and Muscle 2010; 1:7-8 (von Haehling S, Morley JE, Coats AJ, and Anker SD).