Journal article

The impact of glucose disorders on cognition and brain volumes in the elderly: the Sydney Memory and Ageing Study

Katherine Samaras, Helen L Lutgers, Nicole A Kochan, John D Crawford, Lesley V Campbell, Wei Wen, Melissa J Slavin, Bernard T Baune, Darren M Lipnicki, Henry Brodaty, Julian N Trollor, Perminder S Sachdev

GeroScience | SPRINGER | Published : 2014


Type 2 diabetes predicts accelerated cognitive decline and brain atrophy. We hypothesized that impaired fasting glucose (IFG) and incident glucose disorders have detrimental effects on global cognition and brain volume. We further hypothesized that metabolic and inflammatory derangements accompanying hyperglycaemia contribute to change in brain structure and function. This was a longitudinal study of a community-dwelling elderly cohort with neuropsychological testing (n = 880) and brain volumes by magnetic resonance imaging (n = 312) measured at baseline and 2 years. Primary outcomes were global cognition and total brain volume. Secondary outcomes were cognitive domains (processing speed, me..

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University of Melbourne Researchers


Awarded by Australian Government's National Health and Medical Research Council

Funding Acknowledgements

The study was supported by competitive funding from the Australian Government's National Health and Medical Research Council (Dementia Research Grant 510124). The participants in the Sydney Memory and Ageing Study are thanked for their contribution to the scientific understanding of ageing.