Changes in Insulin Resistance and HbA(1c) Are Related to Exercise-Mediated Changes in Body Composition in Older Adults With Type 2 Diabetes
Yorgi Mavros, Shelley Kay, Kylie A Anderberg, Michael K Baker, Yi Wang, Renru Zhao, Jacinda Meiklejohn, Mike Climstein, Anthony O'Sullivan, Nathan de Vos, Bernhard T Baune, Steven N Blair, David Simar, Kieron Rooney, Nalin Singh, Maria A Fiatarone Singh
Diabetes Care | AMER DIABETES ASSOC | Published : 2013
OBJECTIVE: To investigate changes in body composition after 12 months of high-intensity progressive resistance training (PRT) in relation to changes in insulin resistance (IR) or glucose homeostasis in older adults with type 2 diabetes. RESEARCH DESIGN AND METHODS: One-hundred three participants were randomized to receive either PRT or sham exercise 3 days per week for 12 months. Homeostasis model assessment 2 of insulin resistance (HOMA2-IR) and glycosylated hemoglobin (HbA1c) were used as indices of IR and glucose homeostasis. Skeletal muscle mass (SkMM) and total fat mass were assessed using bioelectrical impedance. Visceral adipose tissue, mid-thigh cross-sectional area, and mid-thigh mu..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
The GREAT2DO study was funded by project grant 512381 from the National Health and Medical Research Council (NHMRC), and grants from The Australian Diabetes Society and Diabetes Australia. Y.M. was supported by the Australian Postgraduate Award Scholarship. Y.W. was supported by University of Sydney International Postgraduate Research Scholarship.