Journal article
Changes in insulin resistance and HbA1c are related to exercise-mediated changes in body composition in older adults with type 2 diabetes: Interim outcomes from the GREAT2DO trial
Y Mavros, S Kay, KA Anderberg, MK Baker, Y Wang, R Zhao, J Meiklejohn, M Climstein, A O'Sullivan, N De Vos, BT Baune, SN Blair, D Simar, K Rooney, N Singh, MAF Singh
Diabetes Care | AMER DIABETES ASSOC | Published : 2013
DOI: 10.2337/dc12-2196
Abstract
OBJECTIVE-To investigate changes in body composition after 12 months of high-intensity progressive resistance training (PRT) in relation to changes in insulin resistance (IR) or glucose homeostasis in older adults with type 2 diabetes. RESEARCH DESIGN AND METHOD S-One-hundred three participants were randomized to receive either PRT or sham exercise 3 days per week for 12 months. Homeostasis model assessment 2 of insulin resistance (HOMA2-IR) and glycosylated hemoglobin (HbA1c) were used as indices of IR and glucose homeostasis. Skeletal muscle mass (SkMM) and total fat mass were assessed using bioelectrical impedance. Visceral adipose tissue, mid-thigh cross-sectional area, and mid-thigh mus..
View full abstractGrants
Awarded by National Health and Medical Research Council (NHMRC)
Funding Acknowledgements
The GREAT2DO study was funded by project grant 512381 from the National Health and Medical Research Council (NHMRC), and grants from The Australian Diabetes Society and Diabetes Australia. Y.M. was supported by the Australian Postgraduate Award Scholarship. Y.W. was supported by University of Sydney International Postgraduate Research Scholarship.