Possible Associations of NTRK2 Polymorphisms with Antidepressant Treatment Outcome: Findings from an Extended Tag SNP Approach
Johannes M Hennings, Martin A Kohli, Darina Czamara, Maria Giese, Anne Eckert, Christiane Wolf, Angela Heck, Katharina Domschke, Volker Arolt, Bernhard T Baune, Sonja Horstmann, Tanja Brueckl, Torsten Klengel, Andreas Menke, Bertram Mueller-Myhsok, Marcus Ising, Manfred Uhr, Susanne Lucae
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2013
BACKGROUND: Data from clinical studies and results from animal models suggest an involvement of the neurotrophin system in the pathology of depression and antidepressant treatment response. Genetic variations within the genes coding for the brain-derived neurotrophic factor (BDNF) and its key receptor Trkb (NTRK2) may therefore influence the response to antidepressant treatment. METHODS: We performed a single and multi-marker association study with antidepressant treatment outcome in 398 depressed Caucasian inpatients participating in the Munich Antidepressant Response Signature (MARS) project. Two Caucasian replication samples (N = 249 and N = 247) were investigated, resulting in a total nu..View full abstract
Awarded by NGFN-Plus and within the Molecular Diagnostics Program
The study was supported in part by a research grant from the German Federal Ministry for Education and Research (BMBF) in the framework of the National Genome Research Network (NGFN2 and NGFN-Plus, FKZ 01GS0481) and within the Molecular Diagnostics Program (01ES0811). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.The authors have the following interests. Arolt is member of advisory boards and/or gave presentations for the following companies: Astra-Zeneca, Janssen-Organon, Eli Lilly, Lundbeck, Pfizer, Servier, and Wyeth. He also received grants from Astra-Zeneca, Lundbeck, and Wyeth. He chaired the committee for the "Wyeth Research Award Depression and Anxiety''. Czamara was funded by the Deutsche Forschungsgemeinschaft (German Research Foundation) within the framework of the Munich Cluster for Systems Neurology (EXC 1010 SyNergy). Domschke has received speaker fees from Pfizer, Lilly and Bristol-Myers Squibb; she is a consultant for Johnson & Johnson and has received funding by Astra Zeneca. Hennings has received travel support to scientific congresses from Eli Lilly, Bayer Vital and Novartis. Menke, Holsboer inventors: Means and methods for diagnosing predisposition for treatment emergent suicidal ideation (TESI). European application number: 08016477.5. International application number: PCT/EP2009/061575. Uhr is patent holder of WO2005/108605A2 and WO2008/151803A2. Katharina Domschke is a PLOS ONE Editorial Board member. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.