Journal article

KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence

Charles P Morris, Bernhard T Baune, Katharina Domschke, Volker Arolt, Christopher D Swagell, Ian P Hughes, Bruce R Lawford, Ross McD Young, Joanne Voisey

Disease Markers | HINDAWI LTD | Published : 2012

Abstract

KPNA3 is a gene that has been linked to schizophrenia susceptibility. In this study we investigated the possible association between KPNA3 variation and schizophrenia. To investigate a wider role of KPNA3 across psychiatric disorders we also analysed major depression, PTSD, nicotine dependent, alcohol dependent and opiate dependent cohorts. Using a haplotype block-based gene-tagging approach we genotyped six KPNA3 single nucleotide polymorphisms (SNPs) in 157 schizophrenia patients, 121 post-traumatic stress disorder patients, 120 opiate dependent patients, 231 alcohol dependent patients, 147 nicotine dependent patients and 266 major depression patients. One SNP rs2273816 was found to be sig..

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University of Melbourne Researchers