KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence
Charles P Morris, Bernhard T Baune, Katharina Domschke, Volker Arolt, Christopher D Swagell, Ian P Hughes, Bruce R Lawford, Ross McD Young, Joanne Voisey
Disease Markers | HINDAWI LTD | Published : 2012
KPNA3 is a gene that has been linked to schizophrenia susceptibility. In this study we investigated the possible association between KPNA3 variation and schizophrenia. To investigate a wider role of KPNA3 across psychiatric disorders we also analysed major depression, PTSD, nicotine dependent, alcohol dependent and opiate dependent cohorts. Using a haplotype block-based gene-tagging approach we genotyped six KPNA3 single nucleotide polymorphisms (SNPs) in 157 schizophrenia patients, 121 post-traumatic stress disorder patients, 120 opiate dependent patients, 231 alcohol dependent patients, 147 nicotine dependent patients and 266 major depression patients. One SNP rs2273816 was found to be sig..View full abstract
This work was financially supported by the Queensland State Government, the Nicol Foundation and the Institute of Health and Biomedical Innovation, QUT. JV is a Queensland Smart State Fellow.