Journal article

The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study

Julian N Trollor, Evelyn Smith, Emmeline Agars, Stacey A Kuan, Bernhard T Baune, Lesley Campbell, Katherine Samaras, John Crawford, Ora Lux, Nicole A Kochan, Henry Brodaty, Perminder Sachdev

AGE | SPRINGER | Published : 2012


Inflammation may contribute to cognitive decline and dementia. This study examined the cross-sectional relationships between markers of systemic inflammation (C-reactive protein, interleukins-1β, -6, -8, -10, -12, plasminogen activator inhibitor, serum amyloid A, tumour necrosis factor-α and vascular adhesion molecule-1) and cognitive function in 873 non-demented community-dwelling elderly participants aged 70-90 years. Regression analyses were performed to determine the relationships between cognitive domains and inflammatory markers, controlling for age, sex, education, cardiovascular risk factors, obesity and other metabolic factors, smoking, alcohol consumption, depression and presence o..

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University of Melbourne Researchers


Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

This study was supported by a Dementia Research Grant through the Australian National Health and Medical Research Council (Grant ID 510124).The Sydney MAS is supported by the Australian National Health and Medical Research Council Program Grant (Grant ID 350833). The authors wish to acknowledge the contributions of Brain and Ageing Research Program Staff especially Kristan Kang, Simone Reppermund and Melissa Slavin as well all MAS participants.DNA was extracted by Genetic Repositories Australia, which is supported by an Australian National Health and Medical Research Council Grant (grant ID 401184). Arezoo Assareh and Karen Mather undertook the APOE genotyping in the laboratory of Peter Schofield and John Kwok at Neuroscience Research Australia.