Journal article
Brain-derived neurotrophic factor (BDNF) gene: A gender-specific role in cognitive function during normal cognitive aging of the MEMO-Study?
KR Laing, D Mitchell, H Wersching, ME Czira, K Berger, BT Baune
Age | SPRINGER | Published : 2012
Abstract
Cognitive aging processes are underpinned by multiple processes including genetic factors. The brain-derived neurotrophic factor (BDNF) has been suggested to be involved in age-related cognitive decline in otherwise healthy individuals. The genderspecific role of the BDNF gene in cognitive aging remains unclear. The identification of genetic biomarkers might be a useful approach to identify individuals at risk of cognitive decline during healthy aging processes. The aim of this study was to investigate the associations between three singlenucleotide polymorphisms (SNPs) in the BDNF gene and domains of cognitive functioning in normal cognitive aging. The sample, comprising 369 participants (M..
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Funding Acknowledgements
The MEMO-Study is supported by the German Research Society (Deutsch Forschungsgemeinschaft, Grant: BE1996/1-1). Data assessment was done within the framework of the Cooperative Health Research in the Augsburg Region (KORA). Bernhard Baune had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.