A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression

Abstract

Context: The efficacy of antidepressant drug treatment in depression is unsatisfactory; 1 in 3 patients does not fully recover even after several treatment trials. Genetic factors and clinical characteristics contribute to the failure of a favorable treatment outcome. Objective: To identify genetic and clinical determinants of antidepressant drug treatment outcome in depression. Design: Genomewide pharmacogenetic association study with 2 independent replication samples. Setting: We performed a genomewide association study in patients from the Munich Antidepressant Response Signature (MARS) project and in pooled DNA from an independent German replication sample. A set of 328 singlenucleotide ..