Dysbindin (DTNBP1)--a role in psychotic depression?
Katharina Domschke, Bruce Lawford, Ross Young, Joanne Voisey, C Phillip Morris, Tilmann Roehrs, Christa Hohoff, Eva Birosova, Volker Arolt, Bernhard T Baune
Journal of Psychiatric Research | Published : 2011
Previous studies yielded evidence for dysbindin (DTNBP1) to impact the pathogenesis of schizophrenia on the one hand and affective disorders such as bipolar or major depressive disorder (MDD) on the other. Thus, in the present study we investigated whether DTNBP1 variation was associated with psychotic depression as a severe clinical manifestation of MDD possibly constituting an overlapping phenotype between affective disorders and schizophrenia. A sample of 243 Caucasian inpatients with MDD (SCID-I) was genotyped for 12 SNPs spanning 92% of the DTNBP1 gene region. Differences in DTNBP1 genotype distributions across diagnostic subgroups of psychotic (N = 131) vs. non-psychotic depression wer..View full abstract