Study of Mental Activity and Regular Training (SMART) in at risk individuals: a randomised double blind, sham controlled, longitudinal trial.
Nicola J Gates, Michael Valenzuela, Perminder S Sachdev, Nalin A Singh, Bernhard T Baune, Henry Brodaty, Chao Suo, Nidhi Jain, Guy C Wilson, Yi Wang, Michael K Baker, Dominique Williamson, Nasim Foroughi, Maria A Fiatarone Singh
BMC Geriatrics | Published : 2011
BACKGROUND: The extent to which mental and physical exercise may slow cognitive decline in adults with early signs of cognitive impairment is unknown. This article provides the rationale and methodology of the first trial to investigate the isolated and combined effects of cognitive training (CT) and progressive resistance training (PRT) on general cognitive function and functional independence in older adults with early cognitive impairment: Study of Mental and Regular Training (SMART). Our secondary aim is to quantify the differential adaptations to these interventions in terms of brain morphology and function, cardiovascular and metabolic function, exercise capacity, psychological state a..View full abstract