Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD.
Heike Weber, Sarah Kittel-Schneider, Alexandra Gessner, Katharina Domschke, Maria Neuner, Christian P Jacob, Henriette N Buttenschon, Andrea Boreatti-Hümmer, Julia Volkert, Sabine Herterich, Bernhard T Baune, Silke Gross-Lesch, Juliane Kopf, Susanne Kreiker, Thuy Trang Nguyen, Lena Weissflog, Volker Arolt, Ole Mors, Jürgen Deckert, Klaus-Peter Lesch Show all
Neuropsychopharmacology | Published : 2011
Recently, several genome-wide association studies (GWAS) on bipolar disorder (BPD) suggested novel risk genes. However, only few of them were followed up and further, the specificity of these genes is even more elusive. To address these issues, we genotyped SNPs in ANK3, CACNA1C, CMTM8, DGKH, EGFR, and NPAS3, which were significantly associated with BPD in previous GWAS, in a sample of 380 BPD patients. Replicated SNPs were then followed up in patients suffering from unipolar depression (UPD; n=387) or adult attention-deficit/hyperactivity disorder (aADHD; n=535). While we could not confirm an association of ANK3, CACNA1C, and EGFR with BPD, 10 SNPs in DGKH, CMTM8, and NPAS3 were nominally a..View full abstract