Journal article

Altered Amygdala Excitation and CB1 Receptor Modulation of Aggressive Behavior in the Neuroligin-3(R451C) Mouse Model of Autism

Suzanne Hosie, Daniel T Malone, Stephanie Liu, Michelle Glass, Paul Anthony Adlard, Anthony John Hannan, Elisa L Hill-Yardin



Understanding neuronal mechanisms underlying aggression in patients with autism spectrum disorder (ASD) could lead to better treatments and prognosis. The Neuroligin-3 (NL3)R451C mouse model of ASD has a heightened aggressive phenotype, however the biological mechanisms underlying this behavior are unknown. It is well established that NL3R451C mice have imbalanced excitatory and inhibitory synaptic activity in the hippocampus and somatosensory cortex. The amygdala plays a role in modulating aggressive behavior, however potential changes in synaptic activity in this region have not previously been assessed in this model. We investigated whether aggressive behavior is robustly present in mice ..

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Awarded by National Health and Medical Research Council (NHMRC)

Awarded by ARC Future Fellowship

Funding Acknowledgements

This research was funded by a National Health and Medical Research Council (NHMRC) Project Grant APP 1047674 (AJH, EH-Y, DM), NHMRC Principal Research Fellowship (AJH) and a MIPS small grant. The Florey Institute of Neuroscience and Mental Health acknowledge the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. EH-Y was supported by an ARC Future Fellowship (ARC FT 160100126) and an RMIT Vice Chancellor's Senior Research Fellowship while writing the manuscript.