Journal article

Heritable methylation marks associated with breast and prostate cancer risk

Pierre-Antoine Dugue, James G Dowty, Jihoon E Joo, Ee M Wong, Enes Makalic, Daniel F Schmidt, Dallas R English, John L Hopper, John Pedersen, Gianluca Severi, Robert J MacInnis, Roger L Milne, Graham G Giles, Melissa C Southey

PROSTATE | WILEY | Published : 2018

Abstract

BACKGROUND: DNA methylation can mimic the effects of germline mutations in cancer predisposition genes. Recently, we identified twenty-four heritable methylation marks associated with breast cancer risk. As breast and prostate cancer share genetic risk factors, including rare, high-risk mutations (eg, in BRCA2), we hypothesized that some of these heritable methylation marks might also be associated with the risk of prostate cancer. METHODS: We studied 869 incident prostate cancers (430 aggressive and 439 non-aggressive) and 869 matched controls nested within a prospective cohort study. DNA methylation was measured in pre-diagnostic blood samples using the Illumina Infinium HM450K BeadChip. C..

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