Journal article
Heritable methylation marks associated with breast and prostate cancer risk
PA Dugué, JG Dowty, JE Joo, EM Wong, E Makalic, DF Schmidt, DR English, JL Hopper, J Pedersen, G Severi, RJ MacInnis, RL Milne, GG Giles, MC Southey
Prostate | WILEY | Published : 2018
DOI: 10.1002/pros.23654
Abstract
Background: DNA methylation can mimic the effects of germline mutations in cancer predisposition genes. Recently, we identified twenty-four heritable methylation marks associated with breast cancer risk. As breast and prostate cancer share genetic risk factors, including rare, high-risk mutations (eg, in BRCA2), we hypothesized that some of these heritable methylation marks might also be associated with the risk of prostate cancer. Methods: We studied 869 incident prostate cancers (430 aggressive and 439 non-aggressive) and 869 matched controls nested within a prospective cohort study. DNA methylation was measured in pre-diagnostic blood samples using the Illumina Infinium HM450K BeadChip. C..
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Grants
Awarded by VicHealth
Funding Acknowledgements
National Health and Medical Research Council, Grant numbers: 1026892, 1061177, 209057, 396414; Cancer Council Victoria